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AKT-FD Tablet

Lupin Ltd
Tablet
We do not facilitate sale of this product at present
NOT FOR SALE
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Composition FOR AKT-FD

Isoniazid(100mg),Rifampicin(150mg),Ethambutol(267mg),Pyrazinamide(500mg)

food interaction for AKT-FD

alcohol interaction for AKT-FD

pregnancy interaction for AKT-FD

lactation interaction for AKT-FD

food
alcohol
pregnancy
lactation
AKT-FD Tablet is to be taken empty stomach.
Avoid AKT-FD Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
CAUTION
Consuming alcohol while taking AKT-FD Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
UNSAFE
AKT-FD Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
AKT-FD Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE IF PRESCRIBED

SALT INFORMATION FOR AKT-FD

Isoniazid(100mg)

Uses

Isoniazid is used in the treatment of tuberculosis. It is also used to treat inactive (latent) TB .

How it works

Isoniazid is an antibiotic. It works by killing the bacteria that causes tuberculosis.

Common side effects

Peripheral neuropathy (tingling and numbness of feet and hand), Hepatitis (viral infection of liver), Hemolytic anemia, Aplastic anemia, Agranulocytosis (deficiency of granulocytes in the blood), Skin rash, Lethargy, Psychosis, Joint pain, Anemia (low number of red blood cells), Optic neuritis, Deafness, Ringing in ear, Vertigo, Fever, Hypoglycemia (low blood glucose level), Breast enlargement in male, Toxic epidermal necrolysis, Increased white blood cell count (eosinophils), Increased liver enzymes, Pellagra, Drug-induced lupus syndrome, Constipation, Nausea, Pancreatic inflammation
Rifampicin(150mg)

Uses

Rifampicin is used in the treatment of tuberculosis and leprosy.

How it works

Rifampicin is an antibiotic. It works by inactivating a bacterial enzyme (RNA-polymerase) which is required by bacteria to make essential proteins and to reproduce.

Common side effects

Low blood platelets, Dizziness, Vomiting, Nausea, Fever, Abdominal pain, Skin rash, Hemolytic anemia, Acute renal failure, Hepatitis (viral infection of liver), Pseudomembranous colitis, Pseudoadrenal crisis, Toxic epidermal necrolysis, Stevens-Johnson syndrome, Drug allergy, Headache, Chills, Paradoxical reactions, Increased aspartate aminotransferase, Increased alanine aminotransferase, Increased bilirubin in the blood, Decreased white blood cell count (lymphocytes), Diarrhea, Cutaneous reactions, Renal insufficiency, Anaphylactic reaction, Psychotic disorder, Muscle damage, Agranulocytosis (deficiency of granulocytes in the blood), Disseminated intravascular coagulation, Blood in urine
Ethambutol(267mg)

Uses

Ethambutol is used in the treatment of tuberculosis.

How it works

Ethambutol is an antibiotic. It works by slowing the growth of bacteria that causes tuberculosis.

Common side effects

Vomiting, Nausea, Rash, Increased uric acid level in blood, Optic neuritis, Hepatitis (viral infection of liver), Low blood platelets, Decreased white blood cell count (lymphocytes), Decreased white blood cell count (neutrophils), Hypersensitivity, Gout precipitation, Peripheral neuropathy (tingling and numbness of feet and hand), Pneumonitis
Pyrazinamide(500mg)

Uses

Pyrazinamide is used in the treatment of tuberculosis.

How it works

Pyrazinamide is an antitubercular medicine. In the body, it gets converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I (bacterial enzyme), which is essential for bacterial growth. Thus, it works as a bacteriocidal to prohibit their growth and treats tuberculosis.

Common side effects

Hepatitis (viral infection of liver), Joint pain, Skin rash, Nausea, Vomiting, Abdominal pain, Sideroblastic anemia, Fever, General discomfort, Liver tenderness, Hepatomegaly (enlarged liver), Enlarged spleen, Decreased appetite, Flushing (sense of warmth in the face, ears, neck and trunk), Discomfort when urinating

SUBSTITUTES FOR AKT-FD

No substitutes found

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Related Tests

Complete Blood CountErythrocyte Sedimentation RateMycobacterium Tuberculosis DNA PCR - QualitativePeripheral Smear Examination
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Expert advice FOR AKT-FD

  • Your doctor has prescribed Isoniazid to cure your infection and improve symptoms.
  • It is best taken on an empty stomach.
  • You must also take a vitamin B6 supplement while on Isoniazid.
  • Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.

Frequently asked questions FOR AKT-FD

Isoniazid

Q. Is Isoniazid an antibiotic?
Isoniazid is an antibiotic used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)
Q. Is Isoniazid chemotherapy/chemotherapy drug?
Isoniazid is a primary antibiotic used for treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer
Q. Is Isoniazid bacteriostatic or bactericidal?
Isoniazid is a bacteriostatic antibiotic. It stops or suppresses growth of tuberculosis causing bacteria by interfering with the formation of protective outer covering (cell wall) which is essential for their growth
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Q. Is Isoniazid safe?
Yes. Isoniazid is safe if used at prescribed doses for the prescribed duration as advised by your doctor
Q. Is Isoniazid a MAOI?
Isoniazid has very weak inhibitory activity on enzymes monoamine oxidases (MAO); however it is not used as a monoamine oxidase inhibitor (MAOI)
Q. Is Isoniazid a sulfa drug?
No. The chemical structure and mechanism of action of Isoniazid is different from sulfa drugs
Q. Is Isoniazid an inducer or inhibitor?
Isoniazid is an inhibitor (decreases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body
Q. Can I take isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin?
There no known serious drug interactions of isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does Isoniazid cause weight loss/weight gain/hair loss/diarrhea/affect menstruation?
Changes in body weight (gain/loss), hair loss, diarrhea or changes in menstruation are not among the known side effects of Isoniazid. You may experience few of these side effects while on multi drug (including Isoniazid) treatment for tuberculosis
Q. Does Isoniazid cause acne/make you tired/cause constipation?
You may experience unusual tiredness, constipation or acne while on treatment with Isoniazid. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does Isoniazid affect birth control?
Isoniazid has no known interaction with commonly used oral contraceptives (birth control pills). However, multidrug treatment for tuberculosis contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers birth control.

Rifampicin

Q. Is rifampin a penicillin/amoxicillin/sulfa drug?
No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs
Q. Is rifampin bacteriostatic or bactericidal?
Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria
Q. Is rifampin an inducer or inhibitor?
Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body
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Q. What is R-cin 600 used for?
R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections
Q. What is R-cinex/Macox plus/R-cinex 600?
R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid
Q. Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?
Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?
No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections
Q. Does rifampin cause headaches?
Yes. Headache is a possible side effect of rifampin
Q. Does rifampin change urine color/turn urine orange?
Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful
Q. Does rifampin cause liver damage?
Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.

Ethambutol

Q. My child vomited after taking Ethambutol. What should be done?
If your child vomited within 30 minutes of taking Ethambutol, give the same dose again. If vomiting occurred 30 minutes after taking Ethambutol, you need not repeat the dose. If your child vomits again after taking Ethambutol, consult your doctor.
Q. For how long does Ethambutol stay in your system?
Ethambutol stays for about 24 hours in your system. This duration varies from person to person and maybe different for patients with kidney problems.
Q. Will Ethambutol work if I have developed tuberculosis for the second time?
Yes, it will work if you had taken proper treatment and got cured when you developed tuberculosis for the first time. If you have any doubt, ask your doctor.
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Q. Is it necessary to take so many TB drugs simultaneously? Is there no single medicine which can provide a cure for tuberculosis?
Yes, it is important that you take all the prescribed TB drugs together for the recommended duration, else you will not be cured. A single drug is not prescribed to treat TB because it may increase the risk of developing multi-drug resistant tuberculosis, which is very difficult to treat.
Q. What is drug resistance? Can I become resistant to Ethambutol?
Sometimes it happens that bacteria gets modified in your body and stops reacting to the medicine. As a result, the medicine stops working. This is called drug resistance. Drug resistance is uncommon if Ethambutol is used in combination with other TB drugs.
Q. Can Ethambutol treatment be taken for more than two months?
Yes, Ethambutol can be continued for more than 2 months, depending on your condition and as per your doctor’s advice. If after 2 months, your investigations show that the TB bacteria are still active, you may have to take Ethambutol for 1 more month. In case you are resistant to other TB drugs, you may have to take Ethambutol and other TB drugs (for which you are not drug resistant) for longer than 2 months.
Q. What are the warning signals which should prompt me to stop taking Ethambutol?
You should consult your doctor and consider stopping the medicine immediately if you develop any vision problems like blurred vision, color blindness or any kidney problems like decreased amount of urine and swelling of your legs and feet. You may even develop liver troubles like nausea, vomiting and yellowish color of skin and eyes. Beware of all these symptoms and consult your doctor immediately.

Pyrazinamide

Q. What is Pyrazinamide and what is it used for?
Pyrazinamide is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis
Q. Is Pyrazinamide bactericidal?
Pyrazinamide is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases
Q. How does Pyrazinamide work/treat tuberculosis?
Pyrazinamide kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Pyrazinamide is not known
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Q. How does Pyrazinamide cause hyperuricemia and gout?
Following oral intake of Pyrazinamide, it gets converted in the body to pyrazinoic acid (active chemical form of Pyrazinamide). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).

Content on this page was last updated on 16 February, 2024, by Dr. Varun Gupta (MD Pharmacology)