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Wokex 450mg/300mg Tablet

Tablet
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Composition FOR Wokex

Rifampicin(450mg),Isoniazid(300mg)

food interaction for Wokex

alcohol interaction for Wokex

pregnancy interaction for Wokex

lactation interaction for Wokex

food
alcohol
pregnancy
lactation
Wokex 450mg/300mg Tablet is to be taken empty stomach.
Avoid Wokex 450mg/300mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
CAUTION
Consuming alcohol while taking Wokex 450mg/300mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
UNSAFE
Wokex 450mg/300mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Wokex 450mg/300mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE IF PRESCRIBED

SALT INFORMATION FOR Wokex

Rifampicin(450mg)

Uses

Rifampicin is used in the treatment of tuberculosis and leprosy.

How it works

Rifampicin is an antibiotic. It works by inactivating a bacterial enzyme (RNA-polymerase) which is required by bacteria to make essential proteins and to reproduce.

Common side effects

Low blood platelets, Dizziness, Vomiting, Nausea, Fever, Abdominal pain, Skin rash, Hemolytic anemia, Acute renal failure, Hepatitis (viral infection of liver), Pseudomembranous colitis, Pseudoadrenal crisis, Toxic epidermal necrolysis, Stevens-Johnson syndrome, Drug allergy, Headache, Chills, Paradoxical reactions, Increased aspartate aminotransferase, Increased alanine aminotransferase, Increased bilirubin in the blood, Decreased white blood cell count (lymphocytes), Diarrhea, Cutaneous reactions, Renal insufficiency, Anaphylactic reaction, Psychotic disorder, Muscle damage, Agranulocytosis (deficiency of granulocytes in the blood), Disseminated intravascular coagulation, Blood in urine
Isoniazid(300mg)

Uses

Isoniazid is used in the treatment of tuberculosis. It is also used to treat inactive (latent) TB .

How it works

Isoniazid is an antibiotic. It works by killing the bacteria that causes tuberculosis.

Common side effects

Peripheral neuropathy (tingling and numbness of feet and hand), Hepatitis (viral infection of liver), Hemolytic anemia, Aplastic anemia, Agranulocytosis (deficiency of granulocytes in the blood), Skin rash, Lethargy, Psychosis, Joint pain, Anemia (low number of red blood cells), Optic neuritis, Deafness, Ringing in ear, Vertigo, Fever, Hypoglycemia (low blood glucose level), Breast enlargement in male, Toxic epidermal necrolysis, Increased white blood cell count (eosinophils), Increased liver enzymes, Pellagra, Drug-induced lupus syndrome, Constipation, Nausea, Pancreatic inflammation

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Related Tests

Erythrocyte Sedimentation RateComplete Blood CountMycobacterium Tuberculosis DNA PCR - QualitativePeripheral Smear Examination
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Expert advice FOR Wokex

  • Your doctor has prescribed Rifampicin to cure your infection and improve symptoms.
  • It is best taken on an empty stomach. If you get an upset stomach, try taking it with small portions of food. 
  • Your urine, tears and other secretions may become orange-red in colour. Avoid using contact lenses since they may become discolored.
  • Tell your doctor about all other medicines you are taking as Rifampicin can interact with many medicines.
  • Avoid taking hormone-based birth control methods as Rifampicin may decrease their effectiveness.
  • Tell your doctor immediately if you experience unusual tiredness or loss of appetite, fever or chills.

Frequently asked questions FOR Wokex

Rifampicin

Q. Is rifampin a penicillin/amoxicillin/sulfa drug?
No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs
Q. Is rifampin bacteriostatic or bactericidal?
Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria
Q. Is rifampin an inducer or inhibitor?
Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body
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Q. What is R-cin 600 used for?
R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections
Q. What is R-cinex/Macox plus/R-cinex 600?
R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid
Q. Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?
Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?
No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections
Q. Does rifampin cause headaches?
Yes. Headache is a possible side effect of rifampin
Q. Does rifampin change urine color/turn urine orange?
Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful
Q. Does rifampin cause liver damage?
Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.

Isoniazid

Q. Is Isoniazid an antibiotic?
Isoniazid is an antibiotic used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)
Q. Is Isoniazid chemotherapy/chemotherapy drug?
Isoniazid is a primary antibiotic used for treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer
Q. Is Isoniazid bacteriostatic or bactericidal?
Isoniazid is a bacteriostatic antibiotic. It stops or suppresses growth of tuberculosis causing bacteria by interfering with the formation of protective outer covering (cell wall) which is essential for their growth
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Q. Is Isoniazid safe?
Yes. Isoniazid is safe if used at prescribed doses for the prescribed duration as advised by your doctor
Q. Is Isoniazid a MAOI?
Isoniazid has very weak inhibitory activity on enzymes monoamine oxidases (MAO); however it is not used as a monoamine oxidase inhibitor (MAOI)
Q. Is Isoniazid a sulfa drug?
No. The chemical structure and mechanism of action of Isoniazid is different from sulfa drugs
Q. Is Isoniazid an inducer or inhibitor?
Isoniazid is an inhibitor (decreases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body
Q. Can I take isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin?
There no known serious drug interactions of isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does Isoniazid cause weight loss/weight gain/hair loss/diarrhea/affect menstruation?
Changes in body weight (gain/loss), hair loss, diarrhea or changes in menstruation are not among the known side effects of Isoniazid. You may experience few of these side effects while on multi drug (including Isoniazid) treatment for tuberculosis
Q. Does Isoniazid cause acne/make you tired/cause constipation?
You may experience unusual tiredness, constipation or acne while on treatment with Isoniazid. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does Isoniazid affect birth control?
Isoniazid has no known interaction with commonly used oral contraceptives (birth control pills). However, multidrug treatment for tuberculosis contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers birth control.

Content on this page was last updated on 11 October, 2024, by Dr. Varun Gupta (MD Pharmacology)