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Prezil NM 75mg/10mg/1500mcg Tablet SR

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Composition FOR Prezil NM

Pregabalin(75mg),Nortriptyline(10mg),Methylcobalamin(1500mcg)

food interaction for Prezil NM

alcohol interaction for Prezil NM

pregnancy interaction for Prezil NM

lactation interaction for Prezil NM

food
alcohol
pregnancy
lactation
Prezil NM 75mg/10mg/1500mcg Tablet SR may be taken with or without food, but it is better to take it at a fixed time.
None
CAUTION
Prezil NM 75mg/10mg/1500mcg Tablet SR may cause excessive drowsiness with alcohol.
UNSAFE
Prezil NM 75mg/10mg/1500mcg Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Prezil NM 75mg/10mg/1500mcg Tablet SR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
CONSULT YOUR DOCTOR

SALT INFORMATION FOR Prezil NM

Pregabalin(75mg)

Uses

Pregabalin is used in the treatment of neuropathic pain, fibromyalgia and epilepsy/seizures.

How it works

Pregabalin is an antiepileptic medication. When given for epilepsy, it is believed to work by reducing the abnormal electrical activity in the brain, thus preventing seizures. It is also used to treat nerve pain where it blocks pain by interfering with pain signals travelling through the damaged nerves and the brain. For treatment of anxiety, it is believed to work by stopping the release of certain chemical messengers (neurotransmitters) that make you feel anxious.

Common side effects

Sleepiness, Weight gain, Dryness in mouth, Blurred vision, Dizziness, Headache, Peripheral edema, Fluctuating blood pressure, Hypoglycemia (low blood glucose level), Gastrointestinal intolerance, Low blood platelets, Abnormal gait, Joint pain, Visual disturbance, Nasopharyngitis (inflammation of the throat and nasal passages), Bronchitis (inflammation of the airways), Anaphylactic reaction, Abnormal ECG, Stevens-Johnson syndrome, Heart failure, Blood cell abnormalities, Increased creatine phosphokinase (CPK) level in blood, Infection, Gastrointestinal disturbance
Nortriptyline(10mg)

Uses

Nortriptyline is used in the treatment of depression and bed-wetting. It is used in patients intolerant of or unresponsive to alternative treatment options for depression.

How it works

Nortriptyline is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Common side effects

Weight gain, Orthostatic hypotension (sudden lowering of blood pressure on standing), Dryness in mouth, Constipation, Convulsion, Decreased libido, Vomiting, Nausea, Agitation, Fatigue, Confusion, Dilatation of pupil, Tremors, Taste change, Paresthesia (tingling or pricking sensation), Abnormality of voluntary movements, Headache, Loss of accommodation, Palpitations, Atrioventricular block, Nasal congestion (stuffy nose), Erectile dysfunction, Abnormal ECG, Hypomania, Insomnia (difficulty in sleeping), Ringing in ear, Diarrhea, Rash, Urticaria, Facial swelling, Bone marrow depression, Akathisia (inability to stay still), Involuntary muscle movement
Methylcobalamin(1500mcg)

Uses

Methylcobalamin is used in vitamin B12 deficiency.

How it works

Methylcobalamin is a form of vitamin B12 that restores its level in the body thereby helping in treating certain anemias and nerve problems.

Common side effects

Decreased appetite, Diarrhea, Nausea, Rash

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Expert advice FOR Prezil NM

  • Pregabalin should be taken as per the dose and duration prescribed by your doctor. 
  • It may cause sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • It may cause blurring or loss of vision. Inform your doctor immediately if you notice any vision changes.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • Do not stop taking the medication suddenly without talking to your doctor as it may worsen your underlying condition.

Frequently asked questions FOR Prezil NM

Pregabalin

Q. What is Pregabalin and what is it used for?
Pregabalin belongs to the anticonvulsants class of medicines. It is used to treat seizures. It is also helpful in treating nerve pain (neuropathic pain) which could be due to diabetes, shingles, or injury. It is also used in fibromyalgia (a long-lasting condition that may cause pain, tiredness, muscle stiffness and tenderness as well as difficulty falling or staying asleep. In some cases, your doctor may prescribe this medicine for the treatment of anxiety.
Q. Pregabalin has varied roles. Does it work in the same way for each disease?
No, Pregabalin works in different ways for different diseases. In epilepsy, it stops seizures by reducing the abnormal electrical activity in the brain. In chronic pain, it blocks pain messages travelling from brain to spine.
Q. I have been prescribed Pregabalin for pain due to shingles. When can I expect relief from pain?
It may take a few weeks to see full benefits while taking Pregabalin. However, people have experienced relief from pain after a week of starting Pregabalin.
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Q. How long do I need to take Pregabalin?
Duration for the use of Pregabalin depends on the condition for which you are taking this medicine. If you are taking it for epilepsy, and it is effectively helping you then, you may have to continue it for years. If you are taking it for neuropathic or fibromyalgia pain, it is likely that once your symptoms improve you will have to continue taking it for several months. This will ensure that the problem does not come back. It is advised not to stop taking this medicine without consulting your doctor.
Q. Is it necessary to continue taking Pregabalin even if I feel fine?
Yes, you should not stop taking Pregabalin even if you feel fine. If you are taking it for epilepsy and stop its consumption suddenly, you may have seizures that will not stop. Stopping it suddenly may result in withdrawal symptoms and you may experience anxiety, difficulty in sleeping, feeling sick, pain and sweating. These can be prevented if the dose of Pregabalin is reduced gradually.
Q. Is Pregabalin addictive?
Addiction to Pregabalin is more common in people who take it for unauthorized reasons. Taking Pregabalin more than the recommended doses or taking it for long periods of time may also cause addiction. In addition to that, any person who has a history of drug abuse should never use Pregabalin. In case you feel you are becoming physically dependent on Pregabalin, inform your doctor immediately.
Q. Can I take Diazepam and Pregabalin together?
Yes, Pregabalin and Diazepam can be used together. But, there might be a chance of increased side effects since both these medicines act on the brain to depress excessive activity.
Q. Can the use of Pregabalin cause weight gain?
Yes, Pregabalin may cause weight gain because it increases your hunger. Regular physical exercise and a balanced diet with low-calorie food may help you keep your weight stable. Consult a dietician if you have any further concerns to keep your weight stable.

Nortriptyline

Q. What is Nortriptyline used for?
Nortriptyline is used to treat depression and nocturnal (night time) bedwetting in children. It restores the chemical imbalance in the brain and enhances mood and behavior. In some cases, it may also be prescribed to relieve neuropathic (nerve) pain.
Q. Can I take Nortriptyline for nerve pain? How do I know if I have nerve pain?
Yes, Nortriptyline can be taken for nerve pain. Your doctor may prescribe this medicine in combination with gabapentin. Nerve pain (or neuropathic pain) is commonly described as a shooting, burning or stabbing type of pain that may be associated with tingling, numbness or a pin and needles like feeling. The pain may be spontaneous which means it may be triggered without the presence of any stimulating factor. Additionally, you may experience an increase in the sensitivity to touch. Consult your doctor if you experience such pain.
Q. What are the side effects of Nortriptyline?
The side effects of Nortriptyline are increased heart rate, weight gain, difficulty in urination, orthostatic hypotension (sudden decrease in blood pressure on standing), dryness in mouth and constipation. Please consult your doctor if these side effects do not go away or worry you.
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Q. Is Nortriptyline same as amitriptyline?
Nortriptyline and amitriptyline belong to the same category of medicines with similar action, but their effect may vary upon individual response.
Q. Is Nortriptyline safe?
Nortriptyline is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
Q. Can I just stop taking Nortriptyline?
No, you must not stop taking Nortriptyline suddenly even if you are feeling better as it may worsen your condition. It may also cause withdrawal symptoms such as dizziness, nausea, vomiting, headache, weakness, sleep problems, fever and irritability. Continue taking Nortriptyline for the duration prescribed by your doctor to get maximum benefit. If any of the side effects are bothering you, consult your doctor. In case you have completed your course of treatment, your doctor will reduce your dose gradually before taking you off this medicine completely.
Q. Is there anything I need to be careful about while on therapy with Nortriptyline?
Nortriptyline may cause drowsiness and dizziness, especially in the beginning of the treatment. Do not drive or work with tools or machinery if your alertness is affected. It is not advisable to drink alcohol during treatment with this medicine as it might worsen the drowsiness. Tell your doctor if you have any problems with your liver or kidneys. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding to prevent any harmful effects on the baby.
Q. Can Nortriptyline cause urinary problems?
Yes, Nortriptyline can cause urinary problems. It is more commonly seen in elderly people who are above 65 years of age. The person may face difficulty in passing urine which can further lead to a urinary tract infection. You should consult your doctor immediately if you develop these symptoms.
Q. What if I overdose?
An overdose of Nortriptyline can be significantly dangerous. In case of an overdose, you may experience symptoms such as blurred vision, fast or irregular heartbeats, dry mouth and tongue, fits and fever. You may also experience agitation (anxiety), confusion, hallucinations, uncontrolled movements, low blood pressure, difficulty breathing, discoloration of the skin (turning blue), drowsiness, loss of consciousness, or you may even go into a state of coma. Immediately consult your doctor and seek medical help if you have taken more than the recommended amount of Nortriptyline.
Q. What if I miss a dose of Nortriptyline?
If you have missed a dose of Nortriptyline, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.
Q. What all should I inform my doctor before taking Nortriptyline?
Before taking Nortriptyline, you should tell your doctor if you are allergic to Nortriptyline or any of its ingredients to avoid any allergic reactions. Inform your doctor if you have any problems with your heart, liver, thyroid, prostate or kidneys. Tell your doctor if you have or ever had epilepsy (seizures or fits), diabetes, or glaucoma. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Also, inform your doctor if you are pregnant, planning to conceive or breastfeeding to prevent any harmful effects on the baby.
Q. Is Nortriptyline effective?
Yes, Nortriptyline is effective if taken in the dose and duration prescribed by the doctor. Do not consume more than the recommended dose and avoid skipping doses. Inform your doctor if you experience any side effects while taking Nortriptyline to know about ways to manage or prevent them. It may take a few weeks for you to see improvement in your symptoms. However, the treatment may be continued for a few months for effective management of your condition.

Methylcobalamin

Q. What is Methylcobalamin?
Methylcobalamin contains vitamin B12. Vitamin B12 is an essential nutrient which is required by the body to make red blood cells and maintain a healthy nervous system. It is also important for releasing energy from food and using vitamin B11 (folic acid).
Q. Why can’t I get sufficient vitamin B12 from my diet?
You can get vitamin B12 from sources like meat, fish, eggs and dairy products. While people who are vegetarian or vegan may not get Vitamin B12 as it is not found naturally in foods such as fruits, vegetables and grains. Therefore, deficiency of Vitamin B12 is usually noticed in vegetarians or vegans.
Q. What happens if I have vitamin B12 deficiency?
Deficiency of vitamin B12 may cause tiredness, weakness, constipation, loss of appetite, weight loss and megaloblastic anemia (a condition when red blood cells become larger in size than normal). It may also lead to nerve problems such as numbness and tingling in the hands and feet. Other symptoms of vitamin B12 deficiency may include problems with balance, depression, confusion, dementia, poor memory and soreness of the mouth or tongue.
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Q. How should Methylcobalamin be taken?
Methylcobalamin should be taken in the dose and duration advised by your doctor. It can be taken with or without food. However, it would be best to take it at the same time each day to avoid the chances of missing a dose.
Q. What if I forget to take a dose of Methylcobalamin?
If you forget a dose of Methylcobalamin, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.
Q. Is Methylcobalamin safe?
Methylcobalamin is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

Content on this page was last updated on 10 November, 2024, by Dr. Varun Gupta (MD Pharmacology)