Prucalopride

Information about Prucalopride

Prucalopride uses

Prucalopride is used in the treatment of constipation. It helps in relieving constipation that is long-lasting or keeps coming back.

How prucalopride works

Prucalopride is a selective 5-HT4 receptor agonist that has high intrinsic activity. It indirectly stimulates the release of acetylcholine, a chemical messenger that increases the motility of the intestine and treats even chronic (long-term) constipation very effectively.

Common side effects of prucalopride

Headache, Nausea, Diarrhea, Abdominal pain, Decreased appetite, Dyspepsia, Abnormal gastrointestinal sound, Dizziness, Vomiting, Flatulence, Fatigue, Tremors, Palpitations, Migraine, Rectal bleeding, Fever, General discomfort, Frequent urge to urinate

Available Medicine for Prucalopride

  • ₹237 to ₹373
    Torrent Pharmaceuticals Ltd
    2 variant(s)
  • ₹198 to ₹365
    Torrent Pharmaceuticals Ltd
    2 variant(s)
  • ₹226 to ₹365
    Torrent Pharmaceuticals Ltd
    2 variant(s)
  • ₹209 to ₹359
    Sun Pharmaceutical Industries Ltd
    2 variant(s)
  • ₹232 to ₹366
    Intas Pharmaceuticals Ltd
    2 variant(s)
  • ₹181 to ₹270
    Abbott
    2 variant(s)
  • ₹207 to ₹387
    Lupin Ltd
    2 variant(s)
  • ₹149 to ₹229
    Emcure Pharmaceuticals Ltd
    2 variant(s)
  • ₹154 to ₹254
    Cipla Ltd
    2 variant(s)
  • ₹250
    Lincoln Pharmaceuticals Ltd
    1 variant(s)

Expert advice for Prucalopride

  • Prucalopride helps treat chronic constipation and improve bowel movements, when laxatives have failed to provide adequate relief.
  • It can be taken with or without food, at any time of the day.
  • It may cause diarrhea. Drink plenty of water and inform your doctor if it bothers you.
  • Inform your doctor if your constipation has not improved even after four weeks of taking this medication.

Frequently asked questions for Prucalopride

Prucalopride

Q. How quickly does Prucalopride work?
Prucalopride has been found to act rapidly but the effect varies from person to person. This is because the response to a particular medication varies in every patient. Usually, the medicine generates a bowel movement within 2-3 hours. However, it may take about 4-5 days to show complete effect and rapid bowel movements.
Q. Is Prucalopride safe in pregnancy?
No, Prucalopride is not safe to be taken during pregnancy. There are few reported cases of spontaneous abortion that have been noted when given in pregnant women. There is little evidence of use of Prucalopride in pregnant women. Therefore, its use during pregnancy should be avoided. It is important to consult your doctor before starting this medication.
Q. When should I take Prucalopride?
Prucalopride can be taken at any time of the day. Normally, it is taken orally with or without food once daily. The exact dosage of this medication is to be decided by your prescribing physician. Usually, it is taken as 2 milligrams per day.
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Q. Can Prucalopride cause gastroparesis?
Prucalopride has been proven to be beneficial in cases of gastroparesis and constipation. Gastroparesis is a condition where there is reduced movement of the gut that leads to delayed emptying of the stomach and constipation. Generally, this occurs in conditions like diabetes or after surgery.
Q. When should I avoid taking Prucalopride?
You should avoid taking Prucalopride if you are allergic to it. It should also be avoided if you have a tear in your stomach or intestinal wall, a bowel blockage or inflammatory conditions of the intestinal wall like Crohn’s disease or ulcerative colitis. Always consult your doctor before starting the medication. The doctor should be informed about any ongoing medication and conditions you have.

Content on this page was last updated on 27 September, 2022, by Dr. Varun Gupta (MD Pharmacology)