Pazopanib

Information about Pazopanib

Pazopanib uses

Pazopanib is used in the treatment of kidney cancer and soft tissue sarcoma.

How pazopanib works

Pazopanib is an anti-cancer medication. It works by binding and inhibiting the enzyme receptors (tyrosine kinase) that are responsible for the proliferation of the cancerous cells. It also restricts the growth of new blood vessels within the tumor. This is how it works against cancer.

Common side effects of pazopanib

Headache, Diarrhea, High blood pressure, Decreased appetite, Taste change, Tumor pain, Breathlessness, Low blood platelets, Decreased level of thyroid hormones, Insomnia (difficulty in sleeping), Infection, Hair loss, Nosebleeds, Decreased white blood cell count (neutrophils), Decreased white blood cell count (lymphocytes), Decreased phosphate level in blood, Dehydration, Peripheral sensory neuropathy, Blurred vision, Hot flushes, Venous thromboembolism, Voice change, Coughing up blood, Increased bilirubin in the blood, Liver toxicity, Hypopigmentation, Gingival infection, Infectious peritonitis, Increased hemoglobin, Decreased magnesium level in blood, Hypoesthesia (decreased sensitivity to stimuli), Transient ischemic attacks, Sleepiness, Cerebrovascular accident, Stroke, Retinal detachment, Slow heart rate, Myocardial infarction, Myocardial ischemia, Hypertensive crisis, Runny nose, Pulmonary hemorrhage, Pneumothorax, Pancreatic inflammation, Rectal bleeding, Jaundice, Liver injury, Liver failure, Menorrhagia (heavy menstrual bleeding), Thrombotic microangiopathy, Posterior reversible encephalopathy syndrome, Aneurysm, Interstitial lung disease

Available Medicine for Pazopanib

  • ₹8685 to ₹17370
    Glaxo SmithKline Pharmaceuticals Ltd
    3 variant(s)
  • ₹3500 to ₹6600
    Biocon
    2 variant(s)
  • ₹2200 to ₹4300
    Hetero Healthcare Limited
    2 variant(s)
  • ₹6500 to ₹9000
    Natco Pharma Ltd
    2 variant(s)
  • ₹2000 to ₹3800
    Glenmark Pharmaceuticals Ltd
    2 variant(s)
  • ₹7995 to ₹15900
    Admac Pharma Ltd
    2 variant(s)
  • ₹5211 to ₹10422
    Torrent Pharmaceuticals Ltd
    4 variant(s)
  • ₹6000 to ₹10100
    Khandelwal Laboratories Pvt Ltd
    2 variant(s)
  • ₹2700 to ₹4500
    Medicamen Biotech Ltd
    2 variant(s)
  • ₹5995 to ₹9995
    Cipla Ltd
    2 variant(s)

Frequently asked questions for Pazopanib

Pazopanib

Q. Is Pazopanib a chemotherapy medicine?
Pazopanib is not a conventional chemotherapy medicine. It belongs to a class of medicine called a protein kinase inhibitor. Pazopanib works by preventing the activity of proteins that are involved in the growth and spread of cancer cells.
Q. How should I take Pazopanib?
Pazopanib should be taken orally by mouth once a day or as directed by your doctor. Swallow the tablets whole with water, do not break or crush the tablets. This affects the way the medicine is absorbed and may increase the chance of side effects.
Q. Can Pazopanib be taken with food?
Pazopanib should be taken on an empty stomach, at least 1 hour before or 2 hours after food. If it is taken with food, the dosage may need to be increased. Doing this will in turn cause more side effects.
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Q. How will I know if Pazopanib is helping me?
The duration for which you have to continue taking Pazopanib varies from person to person. The doctor monitors you closely and will be able to better estimate how long the medicine needs to be taken. Do not stop taking it without telling your doctor. It needs to be taken as long as it is effective and you can tolerate it.
Q. Are there any food restrictions while I’m taking Pazopanib?
Yes, it is best to avoid grapefruit and grapefruit juice while on Pazopanib, as it may affect how the medicine works in your body. Ask your doctor about any additional foods you should avoid.
Q. How long I have to take Pazopanib?
The duration for which you have to continue taking Pazopanib varies from person to person. The doctor monitors you closely and will be able to better estimate how long the medicine needs to be taken. Do not stop taking it without telling your doctor. It needs to be taken as long as it is effective and you can tolerate it.
Q. What is the most important information I need to know about Pazopanib?
Pazopanib may cause severe or life-threatening liver damage. Inform your doctor if you have or had liver disease. If you experience any of the following symptoms such as discoloration of the skin or eyes (yellowing), dark urine, extreme tiredness, nausea, vomiting, loss of appetite, pain in the upper right part of the stomach, or unusual bleeding or bruising, call your doctor immediately. Your doctor may ask you to take some lab tests before you start taking Votrient. After you start taking Votrient, you may need to take those lab tests at weeks 3, 5, 7 and 9 and then at months 3 and 4. Your doctor may also prescribe additional tests if necessary. Periodic testing should then continue after 4 months.

Content on this page was last updated on 29 June, 2022, by Dr. Varun Gupta (MD Pharmacology)