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Neostigmine

Information about Neostigmine

Neostigmine uses

Neostigmine is used in the treatment of myasthenia gravis, paralytic ileus, post-operative urinary retention and reversal of effect of skeletal muscle relaxant after surgery.

How neostigmine works

Neostigmine is a reversible cholinesterase inhibitor. It increases the level of acetylcholine, a chemical messenger in the brain, by suppressing acetylcholinesterase (enzyme). This acetylcholine further triggers muscle contracting receptors which helps in muscle contraction.

Common side effects of neostigmine

Nausea, Vomiting, Diarrhea, Excessive salivation, Slow heart rate, Arrhythmia (irregular heartbeats), Headache, Increased sweating, Stomach cramp, Hypotension (low blood pressure)

Available Medicine for Neostigmine

  • Tilstigmin
    ₹51
    Tablets India Limited
    1 variant(s)
  • Myostigmin
    ₹4 to ₹48
    Neon Laboratories Ltd
    3 variant(s)
  • Neotagmin
    ₹21
    Themis Medicare Ltd
    1 variant(s)
  • Tilistigmin
    ₹49
    Tablets India Limited
    1 variant(s)
  • Stigmerase
    ₹23
    Miracalus Pharma Pvt Ltd
    1 variant(s)
  • Neofav
    ₹27
    Favnox Pharmaceuticals Private Limited
    1 variant(s)
  • Myostig
    ₹20
    Arco Lifesciences
    1 variant(s)
  • Neomak
    ₹15
    Makcur Laboratories Ltd.
    1 variant(s)
  • Neomine
    ₹21
    Zydus Cadila
    1 variant(s)
  • Beemine
    ₹21
    Biomiicron Pharmaceuticals
    1 variant(s)

Expert advice for Neostigmine

  • Take it with food to avoid an upset stomach.
  • Take it as per the dose and duration advised by your doctor. Overdosing can result in extreme muscle weakness.
  • It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
  • Do not drink alcohol while taking this medicine as it may worsen the side effects.
  • Inform your doctor if you have an existing kidney problem, parkinson's disease, asthma, or stomach disorders.

Frequently asked questions for Neostigmine

Neostigmine

Q. Does Neostigmine treat myasthenia gravis? How long do I need to take it?
Neostigmine relieves the symptoms of myasthenia gravis but does not cure it. It does so by reducing and improving muscle weakness. The length of time for which you need to take Neostigmine will depend on your condition. Do not stop taking Neostigmine until and unless advised by your doctor, even if you start feeling better.
Q. How long does Neostigmine take to start working?
Neostigmine takes about 5 to 15 minutes to start working and remains effective for 2-4 hours.
Q. Is Neostigmine a steroid?
No, Neostigmine is not a steroid. It belongs to cholinesterase inhibitor group of medicines. Neostigmine work by preventing the breakdown of a chemical called acetylcholine.
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Q. Does it cause weight gain?
No, Neostigmine does not cause weight gain. Your weight gain may be due to inactivity related to muscle weakness in myasthenia gravis.
Q. Is Neostigmine safe to use?
Yes, Neostigmine is safe if used in the dose and duration prescribed by the doctor.
Q. I felt better when I started taking Neostigmine but I have noticed recently that I get tired easily and quickly. Will increasing the dose help me?
If your symptoms have started reappearing, then it could be due to increased severity of myasthenia gravis or excess dose of Neostigmine. Both the conditions have similar effects, so it becomes very difficult to differentiate between the two. Do not increase the dose on your own and consult your doctor immediately.
Q. Can I take Neostigmine for constipation?
No, Neostigmine should not be taken for any type of constipation. However, its use is limited to cases of constipation caused by paralysis of intestine and strictly on prescription by the doctor.
Q. What should I do if I accidentally take more than the dose required?
You should seek immediate medical help in case of overdose of Neostigmine.Excess of Neostigmine may cause stomach pain, nausea, vomiting, diarrhea, blurred vision, difficulty in breathing, and excessive sweating, salivation, and weakness. It can even lead to paralysis.
Q. Does Neostigmine have any abuse potential?
No, there is no evidence of Neostigmine having any abuse potential.
Q. Who should not take Neostigmine?
Neostigmine should not be taken by patients who are allergic to it. Patients who are constipated or cannot urinate should avoid its use, unless advised by the doctor. This is because Neostigmine is only used for certain types of urination problems and constipation (e.g. caused by paralysis of intestine).

Content on this page was last updated on 11 June, 2020, by Dr. Varun Gupta (MD Pharmacology)