Methotrexate

Methotrexate is an immunosuppressant. In rheumatoid arthritis, it works by decreasing the activity of the body's immune system. This decreases swelling, reduces pain and stiffness, and improves function. In psoriasis, it works by slowing down the rapid growth of skin cells.

Abdominal pain, Loss of appetite, Nausea, Vomiting, Increased liver enzymes, Stomatitis (Inflammation of the mouth), Low blood platelets, Joint pain, Diabetes, Headache, Convulsion, Blurred vision, Muscle pain, Mouth ulcer, Hair loss, Decreased white blood cell count, Fatigue, Acne, Diarrhea, Drowsiness, Mood changes, Throat ulcer, Dyspepsia, Herpes zoster, Anemia (low number of red blood cells), Pneumonitis, Exanthema, Erythema (skin redness), Itching, Decreased blood cells (red cells, white cells, and platelets), Agranulocytosis (deficiency of granulocytes in the blood), Hematological disorder, Anaphylactic reaction, Allergic vasculitis, Vertigo, Confusion, Depression, Seizure, Encephalopathy, Vasculitis, Pulmonary fibrosis, Gastrointestinal bleeding, Gastrointestinal ulcer, Pancreatic inflammation, Liver fibrosis, Cirrhosis of the liver, Vaginal inflammation, Urinary bladder inflammation, Osteoporosis, Red spots or bumps, Increased skin pigmentation, Increased rheumatoid nodules, Painful lesions of psoriatic plaque, Pericarditis, Megaloblastic anemia, Visual disturbance, Speech disorder, Myelopathy, Hypotension (low blood pressure), Thromboembolism, Pharyngitis, Apnea (absence of breathing), Bronchial asthma, Gum swelling, Inflammation of the small intestine, Liver toxicity, Renal failure, Low urine output, Anuria, Increased creatinine level in blood, Increased urea nitrogen level in blood, Stress fracture, Nail pigmentation, Petechiae (red or purple spot caused by bleeding into the skin), Ecchymosis (discoloration of the skin resulting from bleeding underneath), Erythema multiforme