Lixisenatide

Information about Lixisenatide

Lixisenatide uses

Lixisenatide is used in the treatment of type 2 diabetes mellitus.

How lixisenatide works

Lixisenatide is an anti-diabetic medication. It works by increasing the release of insulin from pancreas, decreases hormones that raise blood sugar levels, slows down digestion, and reduces appetite.

Common side effects of lixisenatide

Nausea, Vomiting, Diarrhea, Headache, Dizziness, Hypoglycemia (low blood glucose level), Dyspepsia, Constipation, Abdominal distension, Abdominal pain, Hypersensitivity, Injection site reactions (pain, swelling, redness), Pancreatic inflammation

Available Medicine for Lixisenatide

    Expert advice for Lixisenatide

    • If you have been prescribed insulin too, don't inject insulin and Lixisenatide at the same site.
    • Store unused pens in the refrigerator. However, after the first use, you can store it at room temperature for 14 days. 
    • You must discard the pen after 14 days of use even if there is medicine inside the pen.
    • Lixisenatide may cause stomach upset and nausea. To avoid it, eat smaller meals, limit fatty food intake and stop eating when you feel full.
    • It is advisable to drink plenty of water to stay hydrated or to prevent kidney damage while taking this medicine.
    • Notify your doctor immediately if you have severe and/or persistent upper abdominal pain and vomiting.
    • Lixisenatide helps to control blood glucose levels and prevents long-term complications of diabetes.
    • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines (if prescribed) along with Lixisenatide.
    • Inject under the skin of your belly, thighs, or the back of your upper arm.
    • Lixisenatide may cause nausea. To avoid it, eat smaller meals, limit fatty food intake and stop eating when you feel full.
    • If you miss a dose, take it as soon as you remember. If the next dose is within the next 72 hours, then skip the missed dose.
    • Notify your doctor immediately if you have severe and/or persistent upper abdominal pain.
    • Store the pen in the refrigerator. When refrigeration is not possible, you can also keep your pen at room temperature (less than 30°C) for up to 2 weeks.
    • Do not use Lixisenatide if you notice that the pen is damaged, or the medicine does not appear clear and colourless.

    Frequently asked questions for Lixisenatide

    Lixisenatide

    Q. Is Lixisenatide the same as insulin?
    No, Lixisenatide is not the same as insulin. Lixisenatide is a synthetic version of exendin-4 (a hormone). It attaches itself to beta-cells in the pancreas and releases insulin. This increased insulin helps to control blood sugar levels in patients with type II diabetes.
    Q. Does Lixisenatide cause hypoglycemia?
    Lixisenatide itself does not cause hypoglycemia (low blood sugar). However, it may cause low blood sugar when taken with other antidiabetic medicines or insulin.
    Q. Is Lixisenatide safe?
    Lixisenatide is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
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    Q. Does Lixisenatide cause pancreatitis?
    Yes, Lixisenatide may cause pancreatitis (inflammation of the pancreas) in a few people. However, this is very rare and is one of the most serious side effects of Lixisenatide. This can happen any time during the course of treatment and can lead to hospitalization or even death. Consult your doctor immediately if you notice severe abdominal pain, nausea, vomiting or inability to eat as these side effects may be signs and symptoms of pancreatitis.
    Q. How is Lixisenatide administered?
    Lixisenatide is injected just under the skin (subcutaneously) twice daily, usually in the thigh, abdomen (stomach) or upper arm. Your doctor or nurse will show you how and where to inject the medicine. The dose will depend on your condition and what other diabetes medicines you are taking. It is to be used 60 minutes before the morning and evening meal (or two main meals of the day). Use Lixisenatide as prescribed by the doctor and follow the instructions carefully.

    Content on this page was last updated on 29 October, 2024, by Dr. Varun Gupta (MD Pharmacology)