Gliclazide + Pioglitazone + Metformin

This is a combination of three antidiabetic medicines: Gliclazide, Pioglitazone and Metformin. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Gliclazide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Pioglitazone is a thiazolidinedione which increases insulin sensitivity. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and further increasing the body's sensitivity to insulin.

Hypoglycemia (low blood glucose level), Nausea, Diarrhea, Headache, Edema (swelling), Bone fracture, Anemia (low number of red blood cells), Upper respiratory tract infection, Dizziness, Vomiting, Flatulence, Bronchitis (inflammation of the airways), Vitamin B12 deficiency, Indigestion, Abdominal discomfort, Vasculitis, Hypersensitivity, Abnormal liver function tests, Muscle pain, Sinus inflammation, Blood cell abnormalities, Hemolytic anemia, Decreased blood cells (red cells, white cells, and platelets), Bladder cancer, Visual disturbance, Increased alanine aminotransferase, Rhabdomyolysis, Lactic acidosis, Hepatitis (viral infection of liver), Drug eruptions