Glibenclamide + Metformin + Pioglitazone

This is a combination of three antidiabetic medicines: Glibenclamide, Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glibenclamide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity.

Hypoglycemia (low blood glucose level), Nausea, Diarrhea, Headache, Weight gain, Anemia (low number of red blood cells), Vomiting, Flatulence, Vitamin B12 deficiency, Indigestion, Abdominal discomfort, Bladder cancer, Visual disturbance, Increased alanine aminotransferase, Rhabdomyolysis, Lactic acidosis, Hepatitis (viral infection of liver), Drug eruptions