Chlorambucil

Information about Chlorambucil

Chlorambucil uses

Chlorambucil is used in the treatment of blood cancer and Hodgkin’s disease.

How chlorambucil works

Chlorambucil is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Common side effects of chlorambucil

Bone marrow suppression, Pulmonary fibrosis, Liver toxicity, Jaundice, Peripheral neuropathy (tingling and numbness of feet and hand), Secondary malignancies, Infertility, Central nervous system problems, Seizure, Hypersensitivity

Available Medicine for Chlorambucil

  • ₹2324
    Celon Laboratories Ltd
    1 variant(s)
  • ₹960 to ₹2190
    Natco Pharma Ltd
    2 variant(s)
  • ₹2370
    GLS Pharma Ltd.
    1 variant(s)
  • 2 variant(s)

Expert advice for Chlorambucil

  • Chlorambucil should be taken one hour before a meal or two hours after a meal. 

Frequently asked questions for Chlorambucil

Chlorambucil

Q. How is Chlorambucil administered?
Chlorambucil is administered orally in tablet form.
Q. Why is Chlorambucil toxic to cancer cells/ how does Chlorambucil work?
Chlorambucil belongs to a class of drugs called nitrogen mustard derivatives which kill the cancer cells by interfering with DNA replication, and also by directly slowing or stopping their growth.
Q. Does Chlorambucil cause hair loss/constipation?
No, hair loss or constipation has not been reported with the use of Chlorambucil.
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Q. What is Chlorambucil used for?
Chlorambucil is used to treat some types of blood cancers like Hodgkin's disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. It is also used to treat Waldenstrom's macroglobulinaemia (rare blood condition involving the release of an abnormal protein, macroglobulin, into the blood).
Q. How is Chlorambucil excreted?
Chlorambucil is metabolized in liver to form nontoxic compounds which are excreted in urine.
Q. Does Chlorambucil need to be refrigerated?
Chlorambucil has to be stored in a refrigerator at a temperature between 2 °C – 8 °C.

Content on this page was last updated on 30 July, 2022, by Dr. Varun Gupta (MD Pharmacology)