Apremilast
Information about Apremilast
Apremilast uses
Apremilast is used in the treatment of Plaque psoriasis. It is used in patients who have had an inadequate response or have been intolerant to a previous medication.
How apremilast works
Apremilast is a phosphodiesterase 4 (PDE4) inhibitors. It works by blocking the action of certain chemical messengers that are responsible for inflammation associated with psoriatic arthritis and psoriasis, and thereby reduces the signs and symptoms of these conditions.
Common side effects of apremilast
Diarrhea, Nausea, Vomiting, Upper respiratory tract infection, Headache, Tension headache, Bronchitis (inflammation of the airways), Nasopharyngitis (inflammation of the throat and nasal passages), Decreased appetite, Insomnia (difficulty in sleeping), Depression, Migraine, Cough, Dyspepsia, Increased bowel movements, Upper abdominal pain, Gastro-esophageal reflux disease, Back pain, Fatigue, Tooth abscess, Hair follicle inflammation, Joint pain, Hypersensitivity, Suicidal thoughts, Suicidal behaviors, Gastrointestinal bleeding, Rash, Red spots or bumps, Weight loss
Available Medicine for Apremilast
Expert advice for Apremilast
- Apremilast is a well-tolerated medicine. Mild stomach upset may occur early during the treatment.
- Monitor your weight regularly as Apremilast may cause weight loss.
- Your doctor will gradually increase the dose from day 1 to day 6 of treatment, after which it may be kept constant.
- Tell your doctor immediately if you experience new or worsened depression, suicidal thoughts, other mood changes or unexplained weight loss.
Frequently asked questions for Apremilast
Apremilast
Q. Is Apremilast an immunosuppressant?
No, Apremilast is not an immunosuppressant. It belongs to a class of medicines known as phosphodiesterase 4 inhibitors (PDE4) which work by blocking the activity of PDE4. PDE4 is found in inflammatory cells and blocking it helps in reducing the molecules responsible for inflammation.
Q. How long does it take for Apremilast to work?
Apremilast is used to treat plaque psoriasis (red, scaly, thick, itchy, painful patches on skin) and psoriatic arthritis (a condition that causes joint pain and swelling). It is a long-term treatment and may take about 16 weeks to show an improvement.
Q. Can Apremilast cause depression?
Yes, Apremilast may cause depression as a side effect. The patient may also develop suicidal thoughts. It should be avoided in patients with a history of depression. In case you develop any of these symptoms, consult your doctor immediately or ask your friends or relatives to help seek medical advice.