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Open-Up 300 Tablet

Tablet
Rs.365for 1 strip(s) (10 tablets each)
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Composition FOR Open-Up 300mg Tablet

Ursodeoxycholic Acid(300mg)

food interaction for Open-Up Tablet

alcohol interaction for Open-Up Tablet

pregnancy interaction for Open-Up Tablet

lactation interaction for Open-Up Tablet

food
alcohol
pregnancy
lactation
Open-Up 300 Tablet should be taken with or after food.
None
CAUTION
It is not known whether it is safe to consume alcohol with Open-Up 300 Tablet. Please consult your doctor.
CONSULT YOUR DOCTOR
The safety of Open-Up 300 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
CONSULT YOUR DOCTOR
Information regarding the use of Open-Up 300 Tablet during breastfeeding is not available. Please consult your doctor.
CONSULT YOUR DOCTOR

SALT INFORMATION FOR Open-Up 300mg Tablet

Ursodeoxycholic Acid(300mg)

Open-up tablet uses

{med_name} is used in the treatment of gallbladder stones and primary biliary cirrhosis.

How open-up tablet works

Open-Up 300 Tablet is a hepatoprotective medication. It works by reducing the amount of cholesterol in the blood and helps dissolve gallbladder stones that are composed mainly of cholesterol. It also improves liver enzymes, protects liver cells from injury caused due to toxic bile acids, and improves liver function.

Common side effects of open-up tablet

Abdominal pain, Diarrhea, Nausea, Rash, Hair loss, Cough, Sinus inflammation, Upper respiratory tract infection, Urinary tract infection, Allergy, Chest pain, Dyspepsia, Abdominal discomfort, Headache, Itching, Back pain, Fatigue, Flatulence, Vomiting, Joint pain, Joint inflammation, Muscle pain, Insomnia (difficulty in sleeping), Bronchitis (inflammation of the airways)

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Expert advice FOR Open-Up Tablet

  • Ursodeoxycholic Acid should be taken after a meal with a glass of milk or water.
  • Eat a healthy diet, exercise regularly, and avoid alcohol intake.
  • Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
  • Your doctor may monitor your liver function and bilirubin levels every month for the next 3 months after the start of therapy and every 6 months thereafter.
  • Do not stop taking the medication without talking to your doctor.

Frequently asked questions FOR Open-Up 300mg Tablet

Ursodeoxycholic Acid

Q. When should I take Open-Up 300 Tablet?
The suitable timing of taking this medicine might differ depending on your condition. Your doctor might instruct you to take 2 to 3 doses per day and suggest taking the last dose at bedtime. Open-Up 300 Tablet should be taken with water or milk after food. When prescribed for dissolving gallstones, it is usually suggested to be taken once daily at night.
Q. Is Open-Up 300 Tablet safe?
Open-Up 300 Tablet is usually considered to be a safe and effective medicine. However, this medicine may have some common side effects, such as diarrhea. If diarrhea occurs, your doctor may reduce the dose, and if it persists, your treatment may be discontinued. Additionally, using this medicine as a long-term therapy may also affect your liver enzyme levels. To keep a check on this, your doctor will keep monitoring your liver enzyme levels regularly. Despite these minor side effects, this medicine is supposed to be a good alternative to surgery in some patients with gallstones.
Q. How does Open-Up 300 Tablet help the liver?
Open-Up 300 Tablet acts on the liver and gets concentrated in the bile secreted from the liver. This, as a result, suppresses the synthesis and secretion of cholesterol by the liver, thereby decreasing the cholesterol levels in bile. This medicine also acts by stopping the intestines from absorbing the bile salts and cholesterol. So, the reduced cholesterol saturation in the bile from the liver leads to the gradual dissolving of cholesterol from gallstones, leading to a decrease in size and their eventual dissolution. It also reduces elevated liver enzyme levels by increasing the bile flow through the liver, hence protecting the liver cells.
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Q. Does Open-Up 300 Tablet cause weight gain?
Yes, there is a chance of weight gain with Open-Up 300 Tablet, but it is not common. The use of Open-Up 300 Tablet can cause weight gain when prescribed in patients with liver disease associated with chronic stasis of bile in the small bile ducts of the liver. In such conditions, bile cannot flow from the liver to the small intestine. Again, the chance of weight gain varies from person to person depending on the disease, so consult your doctor if you experience weight gain.
Q. What should I avoid while taking Open-Up 300 Tablet?
While taking Open-Up 300 Tablet, avoid taking an antacid preparation without consulting your doctor, as they decrease the effectiveness of Open-Up 300 Tablet. You should also avoid medicines like cholestyramine or colestipol, as they affect the effectiveness of Open-Up 300 Tablet. Ask your doctor about the time gap that should be maintained between Open-Up 300 Tablet and these medicines. Also, avoid taking oral contraceptives, estrogenic hormones, and blood cholesterol-lowering agents such as clofibrate, as they may increase the chances of developing gallstones and act opposite to the Open-Up 300 Tablet.
Q. When should I take Open-Up 300 Tablet?
The suitable timing of taking this medicine might differ depending upon your condition. Your doctor might instruct you to take 2 to 3 doses per day and suggest to take the last dose at bedtime. Open-Up 300 Tablet should be taken with water milk and can be taken with food or after food. When prescribed for dissolving gallstones, it is usually suggested to be taken once daily at night. Ideally, it should be taken at a gap of 6 hours, for example at 8 am, 2 pm and 8 pm.
Q. Is Open-Up 300 Tablet safe?
Open-Up 300 Tablet is usually considered to be a safe and effective medicine. However, this medicine may have some common side effects, such as diarrhea. If diarrhea occurs, your doctor may reduce the dose and if it persists, your treatment may be discontinued. Additionally, using this medicine as a long-term therapy may also affect your liver enzyme levels. To keep a check on this, your doctor will keep monitoring your liver enzyme levels regularly. Despite these minor side effects, this medicine is supposed to be a good alternative to surgery in some patients with gallstones.
Q. How does Open-Up 300 Tablet help the liver?
Open-Up 300 Tablet acts on the liver and gets concentrated in the bile secreted from the liver. This, as a result, suppresses the synthesis and secretion of cholesterol by the liver, thereby decreasing the cholesterol levels in bile. This medicine also acts by stopping the intestines from absorbing the bile salts and cholesterol. So, the reduced cholesterol saturation in the bile from the liver leads to the gradual dissolving of cholesterol from gallstones, leading to a decrease in size and their eventual dissolution. It also reduces elevated liver enzyme levels by increasing the bile flow through the liver, hence protecting the liver cells.
Q. Does Open-Up 300 Tablet cause weight gain?
Yes, there is a chance of weight gain with Open-Up 300 Tablet, but it is not common. The use of Open-Up 300 Tablet can cause weight gain when prescribed in patients with liver disease associated with chronic stasis of bile in small bile ducts of the liver. In such condition, bile cannot flow from the liver to the small intestine. Again, the chance of weight gain varies from person to person depending upon the disease, so consult your doctor if you experience weight gain.
Q. What should I avoid while taking Open-Up 300 Tablet?
While taking Open-Up 300 Tablet, avoid taking an antacid preparation without consulting your doctor, as they decrease the effectiveness of Open-Up 300 Tablet. You should also avoid medicines like cholestyramine or colestipol as they affect the effectiveness of Open-Up 300 Tablet. So, ask your doctor about the time gap that should be maintained between Open-Up 300 Tablet and these medicines. Also, avoid taking oral contraceptives, estrogenic hormones and blood cholesterol-lowering agents such as clofibrate as they may increase the chances of developing gallstones and act opposite to the Open-Up 300 Tablet.

Content on this page was last updated on 21 January, 2026, by Dr. Sachin Gupta (MD Pharmacology, MBBS)