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Composition FOR Apresol Plus

Isosorbide Dinitrate(20mg),Hydralazine(37.5mg)

food interaction for Apresol Plus

alcohol interaction for Apresol Plus

pregnancy interaction for Apresol Plus

lactation interaction for Apresol Plus

food
alcohol
pregnancy
lactation
Apresol Plus Tablet is to be taken with food.
None
CAUTION
Consuming alcohol while taking Apresol Plus Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
UNSAFE
Apresol Plus Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Apresol Plus Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE IF PRESCRIBED

SALT INFORMATION FOR Apresol Plus

Isosorbide Dinitrate(20mg)

Uses

Isosorbide Dinitrate is used in the treatment of Angina (heart-related chest pain) and Heart failure.

How it works

Isosorbide Dinitrate is a nitrate. It works by relaxing the blood vessels which decreases the oxygen demand of the heart and reduces its workload, thereby preventing/treating attacks of angina (chest pain).

Common side effects

Headache, Lightheadedness, Fainting, Hypotension (low blood pressure), Rebound hypertension, Methemoglobinemia (presence of methemoglobin in the blood), Allergic reaction
Hydralazine(37.5mg)

Uses

Hydralazine is used in the treatment of Hypertension (high blood pressure). It is also used in combination with long-acting nitrates in heart failure.

How it works

Hydralazine is a potassium channel opener. It works by relaxing blood vessels which lowers blood pressure and allows more blood and oxygen to reach the heart and other organs.

Common side effects

Diarrhea, Headache, Nausea, Palpitations, Vomiting, Angina pectoris, Constipation, Decreased appetite, Tachycardia, Hypotension (low blood pressure), Anemia (low number of red blood cells), Difficulty in urination, Systemic lupus erythematosus, Hypersensitivity reaction, Polyneuritis, Protein in urine

SUBSTITUTES FOR Apresol Plus

10 Substitutes
10 Substitutes
Sorted By
RelevancePrice
  • Isorus Tablet
    (15 tablets in strip)
    Ajanta Pharma Ltd
    Rs. 11.73/Tablet
    Tablet
    Rs. 183.50
    pay 16% more per Tablet
  • Nitrohart Tablet
    (10 tablets in strip)
    Mankind Pharma Ltd
    Rs. 7.90/Tablet
    Tablet
    Rs. 82.50
    save 22% more per Tablet
  • Isolazine Tablet
    (15 tablets in strip)
    Lupin Ltd
    Rs. 13.27/Tablet
    Tablet
    Rs. 209.60
    pay 31% more per Tablet
  • Isolazine Tablet
    (10 tablets in strip)
    Lupin Ltd
    Rs. 8.43/Tablet
    Tablet
    Rs. 87
    save 17% more per Tablet
  • Isorus Tablet
    (10 tablets in strip)
    Ajanta Pharma Ltd
    Rs. 8.39/Tablet
    Tablet
    Rs. 86.50
    save 17% more per Tablet

Expert advice FOR Apresol Plus

  • Eat healthy (low-fat, high-fiber, low-sodium diet), quit smoking, increase your physical activity, watch your weight and reduce stress.
  • Isosorbide Dinitrate may cause dizziness or sleepiness. Do not drive or do anything that requires concentration until you know how it affects you.
  • Do not consume alcohol while taking Isosorbide Dinitrate as it may cause increased dizziness.
  • It may cause headaches which usually go away after a few days of continued treatment. Inform your doctor if it persists.
  • You may develop tolerance to Isosorbide Dinitrate with time, meaning that the same dose may be less effective next time. Follow the prescribed dosing schedule to avoid this.
  • Stop taking medications (prescribed for erectile dysfunction) like sildenafil or tadalafil while on treatment with Isosorbide Dinitrate as it may cause low blood pressure.

Frequently asked questions FOR Apresol Plus

Isosorbide Dinitrate

Q. What is Isosorbide Dinitrate and what is it used for?
Isosorbide Dinitrate belongs to a group of medicines called organic nitrates. Isosorbide Dinitrate is used to prevent and treat angina pectoris and as an adjunctive treatment in severe acute or chronic congestive cardiac failure.
Q. How does Isosorbide Dinitrate work?
Isosorbide Dinitrate works by widening the blood vessels in your heart to allow an increased amount of blood flow to areas which need it.
Q. Does Isosorbide Dinitrate lower heart rate?
No, Isosorbide Dinitrate does not lower heart rate. However, in some cases, one may experience reflex tachycardia (fast heart rate) while using nitrates such as Isosorbide Dinitrate.
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Q. Does Isosorbide Dinitrate lower blood pressure?
Yes, Isosorbide Dinitrate lowers blood pressure. This medicine widens the blood vessels and decreases the resistance in them, causing a fall in blood pressure. This fall in blood pressure may in turn decrease the heartbeat which can lead to angina. This medicine should be avoided in people who already have low blood pressure. Discuss with your doctor if you have any concerns.
Q. Can I take sildenafil while taking Isosorbide Dinitrate?
No, you should not take sildenafil along with Isosorbide Dinitrate. Both these medicines lower blood pressure and belong to the same class. Taking these two medicines together may cause significant decrease in blood pressure which can cause fainting or even a heart attack. Along with this, avoid taking other medicines which belong to the same class such as vardenafil and tadalafil.

Hydralazine

Q. What is Hydralazine? What is it used for?
Hydralazine belongs to a class of medicines known as potassium channel openers. It helps in the removal of potassium from the walls of arteries. This results in increased space in the arteries for the blood to flow easily, thereby reducing the workload of the heart to pump the blood. It also improves the blood and oxygen supply to your heart muscle. It is prescribed to patients with stable angina (heart-related chest pain) who cannot take other medicines (beta blockers, calcium channel antagonist) meant for the treatment of angina.
Q. Can I stop taking Hydralazine?
No, you should not stop taking Hydralazine without consulting your doctor. Suddenly stopping the medication may cause reoccurring of your anginal pain. It would be better to consult your doctor if you are experiencing any side effects.
Q. How long does it take Hydralazine to start working?
Hydralazine starts working after about an hour of taking the medicine. However, full benefits may be seen only after 4 to 5 days. Consult your doctor if you do not notice any significant improvement in your condition.
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Q. For how long do I need to continue Hydralazine?
Hydralazine is generally prescribed for a long term. You may even need to take it for the rest of your life. You should continue taking your medicine for as long as your doctor tells you. However, if you experience any bothersome side effects, consult your doctor.
Q. What if somebody accidentally takes an excess of Hydralazine?
Taking Hydralazine in excess may cause low blood pressure and the person may feel weak or dizzy. Also, one may experience irregular or fast heartbeat. In case of an overdose, immediately consult the doctor and seek emergency medical help.
Q. Can I take Hydralazine if I am taking aspirin?
You should avoid taking Hydralazine and aspirin together. Taking these two medicines together increases the risk of ulcer or bleeding in the mouth, stomach or intestine. Immediately consult your doctor if you notice blood in your stool or vomit while using Hydralazine.
Q. Who should not use Hydralazine?
People who are allergic to Hydralazine or any of its ingredients should avoid using Hydralazine. Also, patients who have heart problems such as cardiogenic shock or left ventricular failure with low filling pressure or cardiac decompensation or have a build-up of fluid in the lungs (pulmonary edema) should not use Hydralazine. Additionally, it is advised to avoid using Hydralazine in people taking medicines to treat erectile dysfunction (e.g., sildenafil, tadalafil and vardenafil) or medicines to treat pulmonary hypertension (e.g., riociguat). This is because these medicines may interfere with the working of Hydralazine and affect your blood pressure. Fluctuations in blood pressure could also be due to low blood volume.
Q. Can Hydralazine affect my sex life?
No, Hydralazine does not affect your sex life. However, it is not recommended to take Hydralazine with other medications used for the treatment of erectile dysfunction (e.g., sildenafil or tadalafil) or premature ejaculation (e.g., vardenafil or dapoxetine). Taking these together can lead to a serious drop in your blood pressure. Consult your doctor if you are not sure.

Content on this page was last updated on 29 November, 2023, by Dr. Varun Gupta (MD Pharmacology)